Unusual muscle disease in HIV infected patients

S Roedling; D Pearl; H Manji; M G Hanna; J L Holton; R F Miller

doi:10.1136/sti.2003.008474

Unusual muscle disease in HIV infected patients

Sex Transm Infect. 2004 Aug;80(4):315-7. doi: 10.1136/sti.2003.008474.

Authors

S Roedling¹, D Pearl, H Manji, M G Hanna, J L Holton, R F Miller

Affiliation

¹ Patrick Manson Unit, University College London Hospitals, London WC1E 6AU, UK.

Abstract

Two patients presented with proximal muscle weakness, a normal or minor elevation of creatine phosphokinase (CPK) and normal findings on electromyography. Muscle biopsy in one patient revealed CD8+ polymyositis, and in the other showed ddI induced myopathy. These cases illustrate the importance of muscle biopsy in identifying the underlying pathology in HIV infected patients with muscle weakness and little or no abnormality in laboratory investigations.

Publication types

Case Reports
Review

MeSH terms

Anti-HIV Agents / adverse effects
Biopsy
CD8-Positive T-Lymphocytes
Creatine Kinase / metabolism
Diagnosis, Differential
Didanosine / adverse effects
Female
HIV Infections / complications
HIV Infections / enzymology
HIV Infections / pathology*
Humans
Lymphocytosis / complications
Lymphocytosis / diagnosis
Male
Middle Aged
Muscle Weakness / enzymology
Muscle Weakness / pathology*
Muscle Weakness / virology
Muscle, Skeletal / pathology*
Polymyositis / complications
Polymyositis / diagnosis

Substances

Anti-HIV Agents
Creatine Kinase
Didanosine