Chk1 activation and the nuclear/cytoplasmic ratio

Jennifer Pogoriler; Wei Du

doi:10.1016/j.devcel.2004.07.015

Chk1 activation and the nuclear/cytoplasmic ratio

Dev Cell. 2004 Aug;7(2):147-8. doi: 10.1016/j.devcel.2004.07.015.

Authors

Jennifer Pogoriler¹, Wei Du

Affiliation

¹ Ben May Institute for Cancer Research, Committee on Cancer Biology, University of Chicago, 924 East 57th Street, IL 60637 USA.

PMID: 15296709
DOI: 10.1016/j.devcel.2004.07.015

Abstract

ATR and Chk1 are important components of a cell cycle checkpoint pathway. In this issue of Developmental Cell, Conn et al. shed a novel light on the molecular mechanism of Chk1 activation and raise the possibility of a developmental checkpoint that regulates Chk1 in response to the nuclear/cytoplasmic ratio.

Publication types

Comment

MeSH terms

Animals
Cell Cycle
Cell Cycle Proteins / metabolism*
Cell Nucleus / metabolism*
Checkpoint Kinase 1
Cytoplasm / metabolism*
Enzyme Activation
Gene Expression Regulation, Developmental*
Models, Biological
Protein Kinases / metabolism*
Protein Serine-Threonine Kinases / metabolism*
cdc25 Phosphatases / metabolism

Substances

Cell Cycle Proteins
Protein Kinases
Checkpoint Kinase 1
Protein Serine-Threonine Kinases
cdc25 Phosphatases