Studies on synthetic pathway of xylose-containing N-linked oligosaccharides deduced from substrate specificities of the processing enzymes in sycamore cells (Acer pseudoplatanus L.)

Eur J Biochem. 1992 Feb 1;203(3):401-13. doi: 10.1111/j.1432-1033.1992.tb16564.x.

Abstract

We measured the activities of alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase, beta-1,4-mannosyl-glycoprotein beta-1,2-xylosyltransferase and glycoprotein 3-alpha-L-fucosyltransferase in the Golgi fraction of suspension-cultured cells of sycamore (Acer pseudoplatanus L.) using fluorescence-labelled oligosaccharides as acceptor substrates for these transferase reactions. The structures of the pyridylaminated oligosaccharides produced by these reactions were analyzed by two-dimensional sugar mapping using high-performance liquid chromatography. We demonstrated that (formula; see text) was processed to produce by these in vitro reactions. On the basis of these results, we discuss a biosynthetic pathway for xylose containing N-linked oligosaccharides in plant glycoproteins.

MeSH terms

  • Carbohydrate Sequence
  • Cells, Cultured
  • Fluorescence
  • Fucosyltransferases / metabolism
  • Glucosyltransferases / metabolism
  • Glycoproteins / metabolism
  • Kinetics
  • Molecular Sequence Data
  • N-Acetylglucosaminyltransferases*
  • Oligosaccharides / biosynthesis*
  • Pentosyltransferases / metabolism
  • Substrate Specificity
  • Trees
  • UDP Xylose-Protein Xylosyltransferase
  • Xylose / metabolism*

Substances

  • Glycoproteins
  • Oligosaccharides
  • Xylose
  • Fucosyltransferases
  • Glucosyltransferases
  • N-Acetylglucosaminyltransferases
  • UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
  • Pentosyltransferases