The aim of the study was to determine whether cortical midtibial speed of sound (Soundscan 2000, Myriad Ultrasound Systems, Israel) was able to discriminate women who sustained a fracture of the distal radius from normal women and to compare the performance of tibial speed of sound with dual-energy X-ray absorptiometry (DXA) of the distal radius, hip, and lumbar spine. The study population consisted of 40 women with a wrist fracture and 41 healthy age-matched controls. Tibial ultrasound velocity correlated with bone mineral density of the distal forearm (rS = 0.64, p < 0.001), the hip (rS = 0.46, p < 0.001), and the lumbar spine (rS = 0.51, p < 0.001). The mean speed of sound value at the mid-tibia of the wrist fracture patients (3873 m/s) was lower than that of the controls (3913 m/s), but the difference was not statistically significant (p = 0.12). All DXA values were significantly lower in fracture cases. Receiver operating curve analysis showed that mid-tibial ultrasound velocity was less effective than DXA of the distal forearm to discriminate wrist fracture patients from age-matched controls.