Abstract
We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Apoptosis*
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Chlamydia Infections / microbiology
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Chlamydia trachomatis / pathogenicity*
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Genes, bcl-2
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HeLa Cells / microbiology
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Humans
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Membrane Proteins / antagonists & inhibitors*
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Membrane Proteins / metabolism
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Proto-Oncogene Proteins / antagonists & inhibitors*
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins c-bcl-2*
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Staurosporine / pharmacology*
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bcl-2 Homologous Antagonist-Killer Protein
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bcl-2-Associated X Protein
Substances
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BAK1 protein, human
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BAX protein, human
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Membrane Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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bcl-2 Homologous Antagonist-Killer Protein
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bcl-2-Associated X Protein
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Staurosporine