Abstract
Cardiac resynchronization therapy has made assessment of cardiac dyssynchrony clinically important. To test the hypothesis that echocardiographic displacement imaging can quantify dyssynchrony, 22 patients with left bundle branch block (LBBB), 14 with idiopathic dilated cardiomyopathy (IDC) without electrical conduction delay, and 22 normal controls were studied using radial angle-corrected displacement imaging. Control subjects had coordinated wall movement, whereas patients with LBBB had dyssynchrony characterized by early inward anteroseptal movement and markedly delayed posterior, lateral, or inferior regions (157 +/- 99 ms; p <0.001 vs normal). An interesting subset of patients with IDC without conduction delay (36%) had dyssynchrony with anteroseptal to posterior wall delays of 169 +/- 56 ms (p <0.001 vs normal), similar to patients with LBBB.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Bundle-Branch Block / diagnostic imaging*
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Bundle-Branch Block / physiopathology
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Bundle-Branch Block / therapy
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Cardiomyopathy, Dilated / diagnostic imaging*
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Cardiomyopathy, Dilated / physiopathology
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Cardiomyopathy, Dilated / therapy
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Coronary Disease / diagnostic imaging
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Coronary Disease / physiopathology
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Coronary Disease / therapy
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Echocardiography*
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Echocardiography, Doppler, Color*
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Electrocardiography*
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Female
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Heart Failure / diagnostic imaging*
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Heart Failure / physiopathology
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Heart Failure / therapy
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Heart Septum / diagnostic imaging
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Heart Septum / physiopathology
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Humans
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Image Processing, Computer-Assisted*
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Male
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Middle Aged
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Myocardial Contraction / physiology*
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Reference Values
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Ventricular Dysfunction, Left / diagnostic imaging*
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Ventricular Dysfunction, Left / physiopathology
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Ventricular Dysfunction, Left / therapy
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Ventricular Function, Left / physiology