Abstract
The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Carbolines / chemical synthesis*
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Catalysis
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Cyclization
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Hydrogen Bonding
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Imines / chemistry
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Indole Alkaloids / chemical synthesis
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Stereoisomerism
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Thiourea / analogs & derivatives*
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Thiourea / chemistry
Substances
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Carbolines
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Imines
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Indole Alkaloids
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Thiourea