Abstract
The susceptibility of 135 vancomycin-resistant Enterococcus faecium bacteremic isolates to linezolid and quinupristin-dalfopristin was determined. All were susceptible to linezolid, while 88% were susceptible to quinupristin-dalfopristin prior to the clinical use of the drugs at our hospital. More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene.
MeSH terms
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Acetamides / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Drug Utilization
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Electrophoresis, Gel, Pulsed-Field
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Enterococcus faecium / drug effects*
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Gram-Positive Bacterial Infections / epidemiology*
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Gram-Positive Bacterial Infections / microbiology*
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Humans
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Linezolid
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Oxazolidinones / pharmacology*
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Point Mutation / genetics
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RNA, Bacterial / genetics
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RNA, Ribosomal, 23S / genetics
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Vancomycin Resistance*
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Virginiamycin / analogs & derivatives*
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Virginiamycin / pharmacology*
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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RNA, Bacterial
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RNA, Ribosomal, 23S
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Virginiamycin
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quinupristin
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Linezolid