Abstract
The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21ras may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21ras in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21ras may play a role in the regulation of T cell growth by IL-2.
MeSH terms
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Antigens, Differentiation, T-Lymphocyte / physiology
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CD3 Complex
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Cells, Cultured
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DNA / biosynthesis
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Dose-Response Relationship, Drug
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GTP Phosphohydrolases / physiology
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Guanosine Triphosphate / metabolism
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Humans
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Interleukin-2 / pharmacology*
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Proto-Oncogene Proteins p21(ras) / analysis*
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Proto-Oncogene Proteins p21(ras) / physiology
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Receptors, Antigen, T-Cell / physiology
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Receptors, Interleukin-2 / analysis
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T-Lymphocytes / drug effects*
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T-Lymphocytes / physiology
Substances
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Antigens, Differentiation, T-Lymphocyte
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CD3 Complex
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Interleukin-2
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Receptors, Antigen, T-Cell
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Receptors, Interleukin-2
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Guanosine Triphosphate
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DNA
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GTP Phosphohydrolases
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HRAS protein, human
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Proto-Oncogene Proteins p21(ras)