Abstract
[structure: see text] A novel pentacyclic alkaloid, citrinadin A (1), was isolated from the cultured broth of the fungus Penicillium citrinum, which was separated from a marine red alga, and the structure was elucidated by spectroscopic data. The relative stereochemistry of the pentacyclic core was assigned on the basis of NOESY data and (1)H-(1)H coupling constants, and the presence of an N,N-dimethyl-L-valine residue in 1 was determined by chiral HPLC analysis of the hydrolysate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification*
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Chromatography, High Pressure Liquid
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Indole Alkaloids
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Penicillium / chemistry*
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Quinolizines / chemistry*
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Quinolizines / isolation & purification*
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Rhodophyta
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Valine / analogs & derivatives*
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Valine / chemistry
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Valine / isolation & purification
Substances
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Alkaloids
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Indole Alkaloids
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Quinolizines
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citrinadin A
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Valine