Concise synthesis of isoquinoline via the Ugi and Heck reactions

Zheng Xiang; Tuoping Luo; Kui Lu; Jiayue Cui; Xiaomeng Shi; Reza Fathi; Jiahua Chen; Zhen Yang

doi:10.1021/ol048791n

Concise synthesis of isoquinoline via the Ugi and Heck reactions

Org Lett. 2004 Sep 2;6(18):3155-8. doi: 10.1021/ol048791n.

Authors

Zheng Xiang¹, Tuoping Luo, Kui Lu, Jiayue Cui, Xiaomeng Shi, Reza Fathi, Jiahua Chen, Zhen Yang

Affiliation

¹ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing, 100871, China.

PMID: 15330611
DOI: 10.1021/ol048791n

Abstract

[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction, starting from readily available starting materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Isoquinolines / chemical synthesis*
Molecular Structure

Substances

Isoquinolines