Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy

Byung-Ryul Choi; Myung-Ju Ahn; Woong Soo Lee; Tae-Hwan Kim; Sang-Cheol Bae; Jae-Bum Jun

doi:10.1007/s00296-004-0502-9

Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy

Rheumatol Int. 2005 May;25(4):311-3. doi: 10.1007/s00296-004-0502-9. Epub 2004 Aug 25.

Authors

Byung-Ryul Choi¹, Myung-Ju Ahn, Woong Soo Lee, Tae-Hwan Kim, Sang-Cheol Bae, Jae-Bum Jun

Affiliation

¹ Hospital for Rheumatic Diseases, Hanyang University, 17 Haengdang-Dong, Sungdong-Gu, Seoul 133-792, Korea.

PMID: 15338190
DOI: 10.1007/s00296-004-0502-9

Abstract

Acute leukemia is uncommonly seen with rheumatoid arthritis during or following treatment with low-dose methotrexate, a safe and effective treatment for the arthritic condition. We describe here a 68-year-old woman with rheumatoid arthritis who developed acute erythroleukemia during low-dose methotrexate therapy (total dose 1702.5 mg). This may be the first such case reported in the literature.

Publication types

Case Reports

MeSH terms

Aged
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / complications*
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / pathology
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Folic Acid / therapeutic use
Humans
Hydroxychloroquine / therapeutic use
Leukemia, Erythroblastic, Acute / etiology*
Leukemia, Erythroblastic, Acute / pathology
Methotrexate / therapeutic use*
Treatment Outcome

Substances

Antirheumatic Agents
Hydroxychloroquine
Folic Acid
Methotrexate