The association between gastroesophageal reflux disease and chronic respiratory diseases are proved in many report. Patient with GERD have a higher prevalence of asthma, chronic cough, lung fibrosis. Recently, it was reported patients with OSAS had significantly more GER event than controls. Antireflux therapy in asthma and chronic cough patient with GERD results in improvement in symptoms. In this paper, I comments and report about influence of GERD on chronic respiratory illness, and influence of an antireflux therapy for an asthmatic having GERD.