Bidirectional promoters regulate the monoallelically expressed Ly49 NK receptors

Immunity. 2004 Jul;21(1):2-3. doi: 10.1016/j.immuni.2004.07.001.

Abstract

Members of the Ly49 gene family of natural killer (NK) cell receptors in mice are expressed in seemingly stochastic combinations such that each NK cell expresses a handful of family members. A transcriptional switch appears to establish this interesting pattern of expression.

Publication types

  • Comment

MeSH terms

  • Alleles
  • Animals
  • Antigens, Ly / metabolism*
  • Gene Expression Regulation*
  • Killer Cells, Natural / metabolism*
  • Lectins, C-Type
  • Mice
  • Mice, Transgenic
  • Promoter Regions, Genetic*
  • Receptors, Immunologic / metabolism*
  • Receptors, NK Cell Lectin-Like

Substances

  • Antigens, Ly
  • Lectins, C-Type
  • Receptors, Immunologic
  • Receptors, NK Cell Lectin-Like