Lack of DNA copy number alterations revealed with comparative genomic hybridization in fibroadenomas of the breast

Luciane R Cavalli; Deborah A Cornelio; Rubens S Lima; Cicero A Urban; Janice D Rone; Iglenir J Cavalli; Bassem R Haddad

doi:10.1016/j.cancergencyto.2004.01.015

Lack of DNA copy number alterations revealed with comparative genomic hybridization in fibroadenomas of the breast

Cancer Genet Cytogenet. 2004 Sep;153(2):173-6. doi: 10.1016/j.cancergencyto.2004.01.015.

Authors

Luciane R Cavalli¹, Deborah A Cornelio, Rubens S Lima, Cicero A Urban, Janice D Rone, Iglenir J Cavalli, Bassem R Haddad

Affiliation

¹ Institute for Molecular and Human Genetics, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Main 4000, Washington, DC 20007, USA.

PMID: 15350309
DOI: 10.1016/j.cancergencyto.2004.01.015

Abstract

There are very few studies reporting DNA copy number changes in fibroadenomas of the breast. Using comparative genomic hybridization, we analyzed 20 paraffin-embedded samples of fibroadenomas of the breast from patients with no familial or previous history of breast cancer. No alterations in the DNA copy number were observed in any of the tumors analyzed, regardless of the chromosomal alterations observed using conventional cytogenetic analysis. We discuss our results and compare them to other reports on fibroadenomas.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / genetics*
Breast Neoplasms / pathology
Breast Neoplasms / surgery
Chromosome Aberrations
DNA, Neoplasm / genetics*
Databases, Nucleic Acid
Female
Fibroadenoma / genetics*
Fibroadenoma / pathology
Fibroadenoma / surgery
Humans
Nucleic Acid Hybridization

Substances

DNA, Neoplasm