Objective: To observe the mRNA expression of Th1/Th2 cytokines in hypopharyngeal neoplasms and to explore the pathogenesis of it.
Method: The gene expression of Th1/Th2 cytokines in patients with hypopharyngeal neoplasms was detected by RT-PCR.
Result: The cytokines expression of Th2 was significantly stronger than Th1 in tissue of hypopharyngeal carcinoma.
Conclusion: The dominant expression of Th2 cytokines in hypopharyngeal neoplasms may inhibit the human immunity and enhance the growth and metastasis of hypopharyngeal carcinoma.