Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids

Toh-Seok Kam; Kooi-Mow Sim; Huey-Shen Pang; Takashi Koyano; Masahiko Hayashi; Kanki Komiyama

doi:10.1016/j.bmcl.2004.06.074

Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids

Bioorg Med Chem Lett. 2004 Sep 6;14(17):4487-9. doi: 10.1016/j.bmcl.2004.06.074.

Authors

Toh-Seok Kam¹, Kooi-Mow Sim, Huey-Shen Pang, Takashi Koyano, Masahiko Hayashi, Kanki Komiyama

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. [email protected]

PMID: 15357977
DOI: 10.1016/j.bmcl.2004.06.074

Abstract

A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Resistance, Multiple / drug effects*
Drug Resistance, Multiple / physiology
Humans
Ibogaine / analogs & derivatives*
Ibogaine / toxicity*
Indole Alkaloids / toxicity*

Substances

Indole Alkaloids
Ibogaine