Abstract
Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Humans
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Methicillin Resistance / drug effects*
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Methicillin Resistance / physiology
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Microbial Sensitivity Tests
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Naphthoquinones / chemical synthesis*
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Naphthoquinones / pharmacology*
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / growth & development
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Naphthoquinones
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Sesquiterpenes
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mansonone F