Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia

Tenn Med. 2004 Jul;97(7):317-8.

Abstract

Primary generalized dystonia (PGD) associated with the early-onset generalized dystonia gene (DYT1) can cause severe disability, compromising an individual's ability to perform activities of daily living. Pharmacological treatment has been inadequate in alleviating the motor dysfunctions. Deep brain stimulation of the bilateral globus pallidus internus (DBS B-GPi) has been documented to reduce these debilitating motor abnormalities. This report details the successful treatment of a DYT1-positive 13 year-old boy suffering from PGD.

Publication types

  • Case Reports

MeSH terms

  • Botulinum Toxins / therapeutic use
  • Child
  • Deep Brain Stimulation / methods*
  • Diazepam / therapeutic use
  • Dystonia / genetics
  • Dystonia / physiopathology
  • Dystonia / therapy*
  • Globus Pallidus / surgery*
  • Humans
  • Male
  • Methadone / therapeutic use
  • Treatment Outcome

Substances

  • Botulinum Toxins
  • Diazepam
  • Methadone