An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population

Yanbin Jia; Xin Yu; Boyu Zhang; Yanbo Yuan; Qi Xu; Yucun Shen; Yan Shen

doi:10.1016/j.eurpsy.2004.07.006

An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population

Eur Psychiatry. 2004 Sep;19(6):377-9. doi: 10.1016/j.eurpsy.2004.07.006.

Authors

Yanbin Jia¹, Xin Yu, Boyu Zhang, Yanbo Yuan, Qi Xu, Yucun Shen, Yan Shen

Affiliation

¹ National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

PMID: 15363479
DOI: 10.1016/j.eurpsy.2004.07.006

Abstract

We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
China
DNA Primers / genetics
Enzyme Activation
Female
Gene Expression / genetics*
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
International Classification of Diseases
Male
Mixed Function Oxygenases / genetics*
Neuropsychological Tests
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide / genetics
Schizophrenia, Paranoid / diagnosis
Schizophrenia, Paranoid / ethnology*
Schizophrenia, Paranoid / genetics*
Tyrosine 3-Monooxygenase / genetics*

Substances

DNA Primers
Mixed Function Oxygenases
tryptophan 2-monooxygenase
Tyrosine 3-Monooxygenase