[Pathogenic mechanisms of autoimmune diseases]

B Bonnotte

doi:10.1016/j.revmed.2004.02.003

[Pathogenic mechanisms of autoimmune diseases]

Rev Med Interne. 2004 Sep;25(9):648-58. doi: 10.1016/j.revmed.2004.02.003.

[Article in French]

Author

B Bonnotte¹

Affiliation

¹ Inserm U517, faculté de médecine, service d'immunologie clinique et de médecine interne, centre hospitalo-universitaire du Bocage, Dijon, France. [email protected]

PMID: 15363620
DOI: 10.1016/j.revmed.2004.02.003

Abstract

Background: Auto-immune diseases are a fascinating but poorly understood group of diseases.

Major points: In this review, we will consider genetic susceptibility to auto-immune diseases, initiation of autoreactivity and changes in pathologic processes. Recent physiopathological hypotheses are detailed with clinical examples.

Perspectives: A better knowledge of the physiopathological mechanisms would allow the development of more efficacious treatments.

Publication types

English Abstract
Review

MeSH terms

Animals
Autoantibodies / immunology
Autoantigens / immunology
Autoimmune Diseases / etiology*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology
Autoimmune Diseases / physiopathology
Autoimmunity
B-Lymphocytes / immunology
Complement System Proteins / immunology
Genetic Predisposition to Disease
Humans
Immune Tolerance
Immunoglobulins / immunology
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Rats
Rats, Inbred Lew
T-Lymphocytes / immunology
Thymus Gland / immunology

Substances

Autoantibodies
Autoantigens
Immunoglobulins
Complement System Proteins