Abstract
Pneumococcal protein vaccine based on pneumococcal surface protein A (PspA) is in development with the potential to offer broad range of protection against different strains. We have investigated the frequency of PspA family 1 (Fam1) and family 2 (Fam2) proteins among Streptococcus pneumoniae recovered from ongoing surveillance in Brazil. Fam1 and Fam2 were expressed in comparable rates among 366 isolates, with the potential coverage of 94.3%. PspA families were not associated to age group or source of isolates. However, considering the significant tendency of increasing prevalence of Fam2 associated to widespread dissemination of the genetically-related resistant strains, the monitoring of the PspA families derived from population-based data may be necessary in the context of vaccine development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Bacterial Proteins / analysis*
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology*
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Blotting, Western
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Body Fluids / microbiology
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Brazil
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Child
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Child, Preschool
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DNA, Bacterial / analysis
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Humans
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Infant
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Middle Aged
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Nasopharynx / microbiology
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Penicillin Resistance
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Pneumococcal Infections / microbiology*
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Pneumococcal Vaccines / chemistry
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Pneumococcal Vaccines / immunology*
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Polymerase Chain Reaction
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Population Surveillance
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Serotyping
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Streptococcus pneumoniae / chemistry
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Streptococcus pneumoniae / classification
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Streptococcus pneumoniae / immunology*
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Streptococcus pneumoniae / isolation & purification*
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Vaccines, Subunit / chemistry
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Vaccines, Subunit / immunology
Substances
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Bacterial Proteins
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DNA, Bacterial
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Pneumococcal Vaccines
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Vaccines, Subunit
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pneumococcal surface protein A