Watching the DNA repair ensemble dance

Cell. 2004 Sep 17;118(6):666-8. doi: 10.1016/j.cell.2004.09.006.

Abstract

Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes, adaptor proteins, and chromatin constituents. In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Nucleus / genetics*
  • Cell Nucleus / metabolism
  • Cell Nucleus / ultrastructure
  • DNA / genetics*
  • DNA / metabolism
  • DNA Damage / genetics*
  • DNA Repair / genetics*
  • Diagnostic Imaging / instrumentation
  • Diagnostic Imaging / methods
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Phosphotransferases / genetics
  • Phosphotransferases / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae / ultrastructure

Substances

  • Cell Cycle Proteins
  • Nuclear Proteins
  • DNA
  • Phosphotransferases