Wnt signaling went derailed again: a new track via the LIN-18 receptor?

Cell. 2004 Sep 17;118(6):668-70. doi: 10.1016/j.cell.2004.09.009.

Abstract

In this issue of Cell, Inoue et al. (2004) reports that LIN-18, an atypical receptor tyrosine kinase related to mammalian Ryk and Drosophila Derailed, mediates Wnt signaling in parallel to LIN-17/Frizzled (Fz) during worm vulval development. LIN-18/Ryk and LIN-17/Fz appear to exhibit distinct Wnt specificity, and surprisingly, the LIN-18 intracellular domain may be dispensable.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Drosophila Proteins / genetics*
  • Gene Expression Regulation, Developmental / genetics
  • Protein Structure, Tertiary / genetics
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction / genetics
  • Wnt Proteins

Substances

  • Caenorhabditis elegans Proteins
  • Drosophila Proteins
  • LIN-17 protein, C elegans
  • Proto-Oncogene Proteins
  • Receptors, G-Protein-Coupled
  • Wnt Proteins
  • DRL protein, Drosophila
  • RYK protein, human
  • Receptor Protein-Tyrosine Kinases