Expression of cell cycle-dependent genes and proliferative state of lymphocytes in aging

S Travali; G Carnazzo; A M Distefano; P Manciagli; C Cosenza; E Fidone; S Petralia; A Bernardini; L Motta; F Stivala

doi:10.1016/0167-4943(90)90005-q

Expression of cell cycle-dependent genes and proliferative state of lymphocytes in aging

Arch Gerontol Geriatr. 1990 Sep-Oct;11(2):133-9. doi: 10.1016/0167-4943(90)90005-q.

Authors

S Travali¹, G Carnazzo, A M Distefano, P Manciagli, C Cosenza, E Fidone, S Petralia, A Bernardini, L Motta, F Stivala

Affiliation

¹ Istituto di Patologia Generale, Università di Catania, Catania, Italy.

PMID: 15374484
DOI: 10.1016/0167-4943(90)90005-q

Abstract

The authors analyzed the expression of some genes involved in the control of T lymphocyte proliferation in a group of healthy elderly subjects. They focused their attention on genes involved in the G(0)/G(1) transition (TK, PCNA, H3, IL2-R) and showed decreased expression in the TK, H3 and IL2-R genes. Using flow cytofluorimetry, delayed transition from the G(0)/G(1) to the S stage was observed.