Abstract
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Arachidonic Acids / metabolism*
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Cytochrome P-450 CYP2J2
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Cytochrome P-450 Enzyme System / metabolism*
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Hydroxylation
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Kidney / physiology
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Membrane Lipids / physiology
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Membranes / physiology
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Mixed Function Oxygenases / metabolism
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Oxygenases / metabolism
Substances
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Arachidonic Acids
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Membrane Lipids
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Cytochrome P-450 Enzyme System
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Mixed Function Oxygenases
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Oxygenases
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arachidonic acid 18-hydroxylase
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Cytochrome P-450 CYP2J2