Heterochromatin: RNA points the way

Curr Biol. 2004 Sep 21;14(18):R759-61. doi: 10.1016/j.cub.2004.09.014.

Abstract

Mutation of the multi-KH domain protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromatin-mediated silencing in Drosophila; it also disrupts the modification of histone H3 at lysine 9, and association of heterochromatin protein 1 on the heterochromatic regions, suggesting a role for DDP1 in heterochromatin formation.

Publication types

  • Review

MeSH terms

  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / physiology
  • Gene Silencing / physiology
  • Heterochromatin / genetics*
  • Heterochromatin / physiology
  • Histones / metabolism*
  • Methylation
  • Models, Biological
  • Mutation / genetics
  • RNA Interference

Substances

  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Dp1 protein, Drosophila
  • Drosophila Proteins
  • Heterochromatin
  • Histones
  • Chromobox Protein Homolog 5