Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5071-4. doi: 10.1016/j.bmcl.2004.07.079.

Abstract

Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed.

Publication types

  • Comparative Study

MeSH terms

  • Aniline Compounds / chemical synthesis*
  • Aniline Compounds / chemistry
  • Aniline Compounds / pharmacology
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology
  • Radioligand Assay
  • Receptors, Metabotropic Glutamate / agonists*
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis
  • Sulfonamides / chemistry
  • Sulfonamides / pharmacology

Substances

  • Aniline Compounds
  • Pyrimidines
  • Receptors, Metabotropic Glutamate
  • Sulfonamides
  • metabotropic glutamate receptor 2