Abstract
Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Aromatase Inhibitors / chemical synthesis*
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Aromatase Inhibitors / chemistry
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Aromatase Inhibitors / pharmacology
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Flavones / chemical synthesis*
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Flavones / chemistry
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Flavones / pharmacology
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Humans
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In Vitro Techniques
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Microsomes / drug effects
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Microsomes / enzymology
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Placenta / ultrastructure
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Structure-Activity Relationship
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology
Substances
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Antineoplastic Agents
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Aromatase Inhibitors
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Flavones
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Triazoles