Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Clin Immunol. 2004 Oct;113(1):64-73. doi: 10.1016/j.clim.2004.05.008.

Abstract

CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

Publication types

  • Retracted Publication

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / pharmacology*
  • CD30 Ligand
  • Carrageenan / adverse effects
  • Intercellular Adhesion Molecule-1 / metabolism
  • Ki-1 Antigen / immunology
  • Lung / immunology
  • Lung / metabolism
  • Lung / pathology
  • Male
  • Membrane Glycoproteins / immunology*
  • Mice
  • P-Selectin / metabolism
  • Pleurisy / chemically induced
  • Pleurisy / immunology
  • Pleurisy / metabolism
  • Pleurisy / prevention & control*
  • Tumor Necrosis Factor-alpha / metabolism
  • Tyrosine / analogs & derivatives*
  • Tyrosine / metabolism

Substances

  • Adjuvants, Immunologic
  • Antibodies, Monoclonal
  • CD30 Ligand
  • Ki-1 Antigen
  • Membrane Glycoproteins
  • P-Selectin
  • Tnfsf8 protein, mouse
  • Tumor Necrosis Factor-alpha
  • Intercellular Adhesion Molecule-1
  • 3-nitrotyrosine
  • Tyrosine
  • Carrageenan