The common physiologic and functional variables that quantify limitation in emphysema patients have been the most common outcomes measured after LVRS. Spirometric values and exercise capacity are merely surrogates, however, for their impact on symptoms and QOL in patients with severe emphysema. Because LVRS has been developed as a surgery to palliate disabling symptoms of emphysema, many studies now have included HRQOL outcomes along with the commonly measured physiologic and functional outcomes. Some studies have centered on the QOL as the primary outcome instead of physiologic variables. Many symptom scales and disease-specific and general instruments of HRQOL have been used for evaluating emphysema patients before and after LVRS. Case-control studies and randomized studies have shown a consistent improvement in symptoms related to emphysema and general QOL. These studies validate the use of LVRS as a palliative therapy for selected patients with emphysema. The NETT suggests that this benefit is applicable primarily to patients with an upper lobe-predominant pattern of emphysema or patients with low exercise capacity. Validation or refinement of these criteria depends on the continued contributions of the many investigators performing LVRS.