Isolation and characterization of five new tetrasaccharide glycosides from the roots of Ipomoea stans and their cytotoxic activity

Ismael León; Raúl G Enríquez; Dino Gnecco; María L Villarreal; Daniel Alonso Cortés; William F Reynolds; Margaret Yu

doi:10.1021/np0400454

Isolation and characterization of five new tetrasaccharide glycosides from the roots of Ipomoea stans and their cytotoxic activity

J Nat Prod. 2004 Sep;67(9):1552-6. doi: 10.1021/np0400454.

Authors

Ismael León¹, Raúl G Enríquez, Dino Gnecco, María L Villarreal, Daniel Alonso Cortés, William F Reynolds, Margaret Yu

Affiliation

¹ Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62210 Cuernavaca, Morelos, México. [email protected]

PMID: 15387658
DOI: 10.1021/np0400454

Abstract

Five new tetrasaccharide glycosides, stansins 1-5, were isolated from the roots of Ipomoea stans, and their structures were elucidated using spectroscopic and chemical methods. Preliminary testing showed the cytotoxicity of 5 toward the OVCAR and UISO-SQC-1 cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Humans
Ipomoea / chemistry*
Mexico
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Polysaccharides / chemistry
Polysaccharides / isolation & purification
Polysaccharides / pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Polysaccharides