Abstract
The present study investigated polymorphisms of the NOTCH 4 gene in two independent samples from India and USA, consisting of patients with schizophrenia and their parents (n = 182, and n = 148 'trios,' respectively). Five DNA markers, namely (GAAG)(n), (TAA)(n), SNP1, SNP2, and (CTG)(n) were evaluated. Transmission distortion, consistent with a modest association was detected among both samples. Additional association studies at this locus are warranted.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Base Sequence
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Family Health
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Female
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Genotype
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Haplotypes
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Humans
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India
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Linkage Disequilibrium
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Male
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Nuclear Family
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Polymorphism, Genetic / genetics*
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Polymorphism, Single Nucleotide / genetics
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Proto-Oncogene Proteins / genetics*
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Receptor, Notch4
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Receptors, Cell Surface / genetics*
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Receptors, Notch
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Schizophrenia / genetics*
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Trinucleotide Repeats / genetics
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United States
Substances
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NOTCH4 protein, human
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Proto-Oncogene Proteins
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Receptor, Notch4
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Receptors, Cell Surface
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Receptors, Notch