Abstract
Sequence comparison of Drosophila melanogaster glucose dehydrogenase, Escherichia coli choline dehydrogenase, Aspergillus niger glucose oxidase and Hansenula polymorpha methanol oxidase indicates that these four diverse flavoproteins are homologous, defining a new family of proteins named the GMC oxidoreductases. These enzymes contain a canonical ADP-binding beta alpha beta-fold close to their amino termini as found in other flavoenzymes. This domain is encoded by a single exon of the D. melanogaster glucose dehydrogenase gene.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alcohol Oxidoreductases / chemistry
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Alcohol Oxidoreductases / metabolism
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Amino Acid Sequence
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Animals
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Bacteria / enzymology
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Catalysis
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Choline Dehydrogenase
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Drosophila melanogaster / enzymology
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Fungi / enzymology
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Glucose 1-Dehydrogenase
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Glucose Dehydrogenases / chemistry
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Glucose Dehydrogenases / metabolism
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Glucose Oxidase / chemistry
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Glucose Oxidase / metabolism
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Molecular Sequence Data
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Oxidoreductases / chemistry
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Oxidoreductases / classification*
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Oxidoreductases / metabolism
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Sequence Homology, Nucleic Acid
Substances
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Oxidoreductases
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Alcohol Oxidoreductases
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Glucose Dehydrogenases
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Glucose 1-Dehydrogenase
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Glucose Oxidase
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methanol oxidase
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Choline Dehydrogenase