Abstract
Human tissue inhibitor of metalloproteinases-1 (TIMP-1), but not TIMP-2, has potent growth-promoting activity for a wide range of human and bovine cells. TIMP-1 seems to be a new cell-growth factor in serum and to stimulate the cells independently of its inhibitory activity.
MeSH terms
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Animals
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Cattle
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Cell Division / drug effects
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Cell Line
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Gingiva / drug effects
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Gingiva / growth & development
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Glycoproteins / physiology*
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Growth Substances / blood*
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Growth Substances / physiology
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Humans
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Metalloendopeptidases / antagonists & inhibitors*
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Neoplasm Proteins / physiology
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Tissue Inhibitor of Metalloproteinase-2
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Tissue Inhibitor of Metalloproteinases
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Tumor Cells, Cultured
Substances
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Glycoproteins
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Growth Substances
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Neoplasm Proteins
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Tissue Inhibitor of Metalloproteinases
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Tissue Inhibitor of Metalloproteinase-2
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Metalloendopeptidases