Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells

A Najid; A Simon; J Cook; H Chable-Rabinovitch; C Delage; A J Chulia; M Rigaud

doi:10.1016/0014-5793(92)80117-y

Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells

FEBS Lett. 1992 Mar 16;299(3):213-7. doi: 10.1016/0014-5793(92)80117-y.

Authors

A Najid¹, A Simon, J Cook, H Chable-Rabinovitch, C Delage, A J Chulia, M Rigaud

Affiliation

¹ CJF INSERM 88-03, Faculté de Médecine, Université de Limoges, France.

PMID: 1544497
DOI: 10.1016/0014-5793(92)80117-y

Abstract

A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 microM, blocks arachidonate metabolism.

Publication types

Comparative Study

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Blood Platelets / drug effects
Cyclooxygenase Inhibitors / pharmacology*
Humans
Leukemia, Experimental
Lipoxygenase Inhibitors / pharmacology*
Macrophages / drug effects
Mice
Triterpenes / chemistry
Triterpenes / pharmacology*
Tumor Cells, Cultured / drug effects
Ursolic Acid

Substances

Antineoplastic Agents, Phytogenic
Cyclooxygenase Inhibitors
Lipoxygenase Inhibitors
Triterpenes