Abstract
Various bioreductive drugs that are potent hypoxic cell cytotoxins can also function as effective potentiators of radiation action when administered in vivo post irradiation. There is evidence that a contributory mechanism to this potentiation is enhanced sensitivity to the bioreductive drugs exhibited by cells that are damaged sublethally by radiation.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Aziridines / therapeutic use*
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Cell Hypoxia / drug effects
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Cell Hypoxia / radiation effects
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Combined Modality Therapy
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Dose-Response Relationship, Drug
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Indolequinones*
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Indoles / therapeutic use*
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Mice
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Mice, Inbred C3H
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Misonidazole / analogs & derivatives*
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Misonidazole / therapeutic use
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Neoplasm Transplantation
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Neoplasms, Experimental / drug therapy
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Neoplasms, Experimental / radiotherapy*
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Nitroimidazoles / therapeutic use*
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Prodrugs / therapeutic use*
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Tirapazamine
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Triazines / therapeutic use*
Substances
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Antineoplastic Agents
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Aziridines
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Indolequinones
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Indoles
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Nitroimidazoles
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Prodrugs
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Triazines
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RB 6145
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Tirapazamine
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1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol
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Misonidazole
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apaziquone