Abstract
The authors reviewed a series of 10 consecutive patients treated with plasma exchange (PE) for acute, severe optic neuritis (ON) largely unresponsive to previous high-dose IV glucocorticosteroids. PE was associated with an improvement of visual acuity according to the study criteria in 7 of 10 patients. On follow-up, three of these patients continued to improve, two remained stable, and two had worsened again. PE may be beneficial as an escalating treatment in a subset of patients with severe ON. A controlled trial is warranted.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adult
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Combined Modality Therapy
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Drug Resistance
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Female
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Follow-Up Studies
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Glucocorticoids / therapeutic use
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Interferon beta-1a
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Interferon beta-1b
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Interferon-beta / therapeutic use
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Male
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / complications
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Optic Neuritis / drug therapy
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Optic Neuritis / etiology
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Optic Neuritis / therapy*
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Plasma Exchange*
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Recurrence
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Retrospective Studies
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Treatment Outcome
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Visual Acuity
Substances
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Glucocorticoids
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Immunoglobulins, Intravenous
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Interferon beta-1b
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Interferon-beta
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Interferon beta-1a