5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5269-73. doi: 10.1016/j.bmcl.2004.08.037.

Abstract

Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.

Publication types

  • Comparative Study

MeSH terms

  • Factor IXa / antagonists & inhibitors*
  • Factor IXa / chemistry*
  • Factor Xa / chemistry*
  • Factor Xa Inhibitors*
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Models, Molecular
  • Stereoisomerism
  • Structure-Activity Relationship
  • Substrate Specificity

Substances

  • Factor Xa Inhibitors
  • Indoles
  • 5-amidinoindole
  • Factor IXa
  • Factor Xa