Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides

Macromol Biosci. 2004 Jun 25;4(6):566-9. doi: 10.1002/mabi.200400030.

Abstract

The synthesis of poly(methyl acrylate)-block-poly(gamma-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / chemistry*
  • Anhydrides / chemistry*
  • Calorimetry, Differential Scanning
  • Polyglutamic Acid / analogs & derivatives*
  • Polyglutamic Acid / chemistry*
  • Polymers / chemical synthesis*
  • Polymethacrylic Acids / chemistry*

Substances

  • Amino Acids
  • Anhydrides
  • Polymers
  • Polymethacrylic Acids
  • poly-gamma-benzyl-L-glutamate
  • polymethacrylic acid
  • Polyglutamic Acid