Abstract
Antimicrobial susceptibility of 120 Helicobacter pylori isolates to metronidazole, tetracycline, clarithromycin, and amoxicillin was determined, and 77.5, 15, 10, and 6.6% of the isolates, respectively, were resistant. Only rdxA inactivation and both rdxA and frxA inactivation were responsible for metronidazole resistance in 66% (8 of 12) and 33% (4 of 12) of the isolates, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Infective Agents / pharmacology*
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Bacterial Proteins / genetics
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Bangladesh / epidemiology
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Drug Resistance, Bacterial / genetics
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Female
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Helicobacter Infections / epidemiology*
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Helicobacter Infections / microbiology
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Helicobacter pylori / drug effects*
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Helicobacter pylori / isolation & purification
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Humans
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Male
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Metronidazole / pharmacology*
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Microbial Sensitivity Tests
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Middle Aged
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Nitroreductases / genetics
Substances
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Anti-Infective Agents
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Bacterial Proteins
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Metronidazole
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Nitroreductases
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RdxA protein, Helicobacter pylori