Acromegaly and heart failure: revisions of the growth hormone/insulin-like growth factor axis and its relation to the cardiovascular system

Th B Twickler; M J M Cramer; S P Senden; P A Doevendans; W R de Vries; D W Erkelens; H P F Koppeschaar

doi:10.1055/s-2004-835368

Acromegaly and heart failure: revisions of the growth hormone/insulin-like growth factor axis and its relation to the cardiovascular system

Semin Vasc Med. 2004 May;4(2):115-20. doi: 10.1055/s-2004-835368.

Authors

Th B Twickler¹, M J M Cramer, S P Senden, P A Doevendans, W R de Vries, D W Erkelens, H P F Koppeschaar

Affiliation

¹ Department of Endocrinology and Metabolic Diseases, Catholic University Nijmegen/Radboud University, Nijmegen, The Netherlands.

PMID: 15478031
DOI: 10.1055/s-2004-835368

Abstract

Cardiomyopathy is a major cause of death in overt acromegaly. Recent progress in research has increasingly revealed the molecular mechanisms concerning growth hormone and insulin-like growth factor in the development of heart failure. In this article, we propose mechanisms according to which heart failure occurs, and we aim to extrapolate this knowledge to more general processes involved in heart failure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acromegaly / physiopathology*
Cardiomyopathy, Hypertrophic / physiopathology
Growth Hormone / blood
Heart Failure / physiopathology
Hemodynamics
Humans
Insulin-Like Growth Factor Binding Proteins / physiology*
Myocytes, Cardiac / physiology
Octreotide / therapeutic use
Ventricular Function, Left / physiology

Substances

Insulin-Like Growth Factor Binding Proteins
Growth Hormone
Octreotide