Abstract
Several brominated indole alkaloids and a diterpene (1-7) were isolated from the dichloromethane extract of the North Sea Bryozoan Flustra foliacea. Alkaloid 4 is a new natural product, whose structure was elucidated by interpretation of spectroscopic data (NMR, mass, UV, and IR). All compounds were tested for their in vitro affinity towards the alpha4beta2* and alpha7* subtype of the neuronal nicotinic acetylcholine receptor (nAChR) using radioligand binding assays. Deformylflustrabromine (3) and deformylflustrabromine B (4) were shown to have affinities in the lower micromolar range for nAChRs, differing in their subtype preference.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / administration & dosage
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Alkaloids / pharmacology
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Alkaloids / therapeutic use
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Animals
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Binding, Competitive / drug effects
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Bryozoa*
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Neuroprotective Agents / administration & dosage
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Nicotinic Antagonists / administration & dosage
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Nicotinic Antagonists / pharmacology*
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Nicotinic Antagonists / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Protein Prenylation
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Rats
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Rats, Sprague-Dawley
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Receptors, Nicotinic / drug effects*
Substances
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Alkaloids
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Neuroprotective Agents
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Nicotinic Antagonists
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Plant Extracts
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Receptors, Nicotinic