Abstract
Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.
MeSH terms
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Animals
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DNA Polymerase beta / antagonists & inhibitors*
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Deoxyuridine / chemistry
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Deoxyuridine / isolation & purification
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Deoxyuridine / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Humans
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Lyases / antagonists & inhibitors*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Porifera / chemistry*
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Quinones / chemistry
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Quinones / isolation & purification
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Quinones / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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17-O-isoprenyldictyoceratin-C
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Enzyme Inhibitors
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Quinones
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Sesquiterpenes
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dictyoceratin-C
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ilimaquinone
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DNA Polymerase beta
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Lyases
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Deoxyuridine