Hyrtiosenolides A and B, two new sesquiterpene gamma-methoxybutenolides and a new sterol from a Red Sea sponge Hyrtios species

Diaa T A Youssef; Abdel Nasser B Singab; Rob W M van Soest; Nobuhiro Fusetani

doi:10.1021/np049853l

Hyrtiosenolides A and B, two new sesquiterpene gamma-methoxybutenolides and a new sterol from a Red Sea sponge Hyrtios species

J Nat Prod. 2004 Oct;67(10):1736-9. doi: 10.1021/np049853l.

Authors

Diaa T A Youssef¹, Abdel Nasser B Singab, Rob W M van Soest, Nobuhiro Fusetani

Affiliation

¹ Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

PMID: 15497952
DOI: 10.1021/np049853l

Abstract

Two new sesquiterpene gamma-methoxybutenolides, hyrtiosenolides A (1) and B (2), together with a new 4alpha-methyl polyoxygenated steroid, hyrtiosterol (3), were isolated from a Red Sea sponge, Hyrtios species. Their structures were elucidated by analysis of their 1D and 2D NMR spectra and HRFABMS. Compounds 1 and 2 showed weak antibacterial activity against Escherichia coli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Escherichia coli / drug effects*
Indian Ocean
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Sterols / chemistry
Sterols / isolation & purification*
Sterols / pharmacology

Substances

Sesquiterpenes
Sterols
hyrtiosenolide A
hyrtiosenolide B
hyrtiosterol