Abstract
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemical synthesis*
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Acridines / chemistry
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Acridines / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Ascorbic Acid / metabolism
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Edetic Acid / chemistry
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Intercalating Agents / chemical synthesis*
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Intercalating Agents / chemistry
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Intercalating Agents / pharmacology
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Iron / metabolism
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Levivirus / drug effects*
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Nucleic Acids / drug effects*
Substances
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Acridines
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Antiviral Agents
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Intercalating Agents
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Nucleic Acids
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Edetic Acid
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Iron
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Ascorbic Acid