Abstract
Previous studies demonstrated that the high-mannose oligosaccharide N linked to the Chlamydia major outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Adhesion*
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Cell Line
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Chlamydia / classification
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Chlamydia / physiology*
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Endothelial Cells / microbiology*
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Epithelial Cells / microbiology*
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Glycoside Hydrolases / metabolism*
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Humans
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Oligosaccharides / metabolism*
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Polysaccharides / metabolism
Substances
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Oligosaccharides
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Polysaccharides
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Glycoside Hydrolases
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glycanase