Rapid detection of ITPA 94C>A and IVS2 + 21A>C gene mutations by real-time fluorescence PCR and in vitro demonstration of effect of ITPA IVS2 + 21A>C polymorphism on splicing efficiency

Clin Chem. 2004 Nov;50(11):2182-4. doi: 10.1373/clinchem.2004.039685.
No abstract available

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Fluorescence
  • Genotype
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Inosine Triphosphatase
  • Point Mutation
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic
  • Predictive Value of Tests
  • Purines / adverse effects
  • Pyrophosphatases / blood
  • Pyrophosphatases / genetics*
  • RNA Splicing
  • Risk Assessment

Substances

  • Antineoplastic Agents
  • Immunosuppressive Agents
  • Purines
  • Pyrophosphatases