Abstract
Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-di-hydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude ex-tract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Brazil
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Chlorocebus aethiops
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Diterpenes / administration & dosage
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Diterpenes / pharmacology
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Diterpenes / therapeutic use
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HIV-1 / drug effects*
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Medicine, Traditional
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Phaeophyceae*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Vero Cells / virology
Substances
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Anti-HIV Agents
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Diterpenes
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Plant Extracts