Abstract
The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod) score of 9.88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age of Onset
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Asia / epidemiology
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Chromosome Disorders / ethnology
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Chromosome Disorders / genetics*
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Chromosome Disorders / metabolism
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Chromosome Mapping
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DNA Mutational Analysis
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Female
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Gene Frequency / genetics
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Genes, Recessive / genetics*
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Genetic Linkage / genetics
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Haplotypes / genetics
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Humans
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Male
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Microsatellite Repeats / genetics
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Middle East / epidemiology
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Mutation / genetics*
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Parkinson Disease / ethnology
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Parkinson Disease / genetics*
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Parkinson Disease / metabolism
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Pedigree
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Protein Kinases / genetics*
Substances
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Genetic Markers
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Protein Kinases
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PTEN-induced putative kinase